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Publikationen AG Soboslay: / Publications Team Soboslay:

2015

Wangala B, Vovor A, Gantin RG, Agbeko YF, Lechner CJ, Huang X, Soboslay PT, Köhler C.
Chemokine levels and parasite- and allergen-specific antibody responses in children and adults with severe or uncomplicated Plasmodium falciparum malaria.
Eur J Microbiol Immunol (Bp). 2015 Mar;5(1):131-41. doi: 10.1556/EUJMI-D-14-00041. Epub 2015 Mar 26.

Hegewald J, Gantin RG, Lechner CJ, Huang X, Agosssou A, Agbeko YF, Soboslay PT, Köhler C.
Cellular cytokine and chemokine responses to parasite antigens and fungus and mite allergens in children co-infected with helminthes and protozoa parasites.
J Inflamm (Lond). 2015 Jan 20;12:5. doi: 10.1186/s12950-015-0050-y.

Rolle AM, Soboslay PT, Reischl G, Hoffmann WH, Pichler BJ, Wiehr S.
Evaluation of the Metabolic Activity of Echinococcus multilocularis in Rodents Using Positron Emission Tomography Tracers.
Mol Imaging Biol. 2015 Jan 6. [Epub ahead of print]

2014

Banla M, Tchalim S, Karabou PK, Gantin RG, Agba AI, Kére-Banla A, Helling-Giese G, Heuschkel C, Schulz-Key H, Soboslay PT.
Sustainable control of onchocerciasis: ocular pathology in onchocerciasis patients treated annually with ivermectin for 23 years: a cohort study.
PLoS One. 2014 Jun 2;9(6):e98411.

Huang X, Grüner B, Lechner CJ, Kern P, Soboslay PT.
Distinctive cytokine, chemokine, and antibody responses in Echinococcus multilocularis-infected patients with cured, stable, or progressive disease.
Med Microbiol Immunol. 2014 Jun;203(3):185-93. doi: 10.1007/s00430-014-0331-8. Epub 2014 Feb 9.

2013

Banla M, Maneh N, Vonor B, Nonon Saa KB, Agba A, Gantin RG, Balo KP, Soboslay PT, Bakondé B. abstract
Tropical endemic limbo-conjunctivitis (TELC) and allergic management: a preliminary study in Togolese children.
J Fr Ophtalmol. 2013 Oct;36(8): 677-82.

Lechner CJ, Komander K, Hegewald J, Huang X, Gantin RG, Soboslay PT, Agossou A, Banla M, Köhler C. abstract
Cytokine and chemokine responses to helminth and protozoan parasites and to fungus and mite allergens in neonates, children, adults, and the elderly.
Immun Ageing. 2013 Jul 15;10(1): 29.

2012

Huang X, Kühne V, Kun JF, Soboslay PT, Lell B, Tp V. abstract
In-vitro characterization of novel and functional regulatory SNPs in the promoter region of IL2 and IL2R alpha in a Gabonese population.
BMC Med Genet. 2012 Dec 7;13: 117.

Lechner CJ, Grüner B, Huang X, Hoffmann WH, Kern P, Soboslay PT. abstract
Parasite-specific IL-17-type cytokine responses and soluble IL-17 receptor levels in Alveolar Echinococcosis patients.
Clin Dev Immunol. 2012; 2012: 735342.

Lechner CJ, Gantin RG, Seeger T, Sarnecka A, Portillo J, Schulz-Key H, Karabou PK, Helling-Giese G, Heuschkel C, Banla M, Soboslay PT. abstract
Chemokines and cytokines in patients with an occult Onchocerca volvulus infection.
Microbes Infect. 2012 May;14(5): 438-46.

2011

Ayimba E, Hegewald J, Ségbéna AY, Gantin RG, Lechner CJ, Agosssou A, Banla M, Soboslay PT. abstract
Proinflammatory and regulatory cytokines and chemokines in infants with uncomplicated and severe Plasmodium falciparum malaria.
Clin Exp Immunol. 2011 Nov;166(2): 218-26.

2010

Soboslay PT, Gantin RG, Banla M, Karabou PK, Agossou A, Douti JK, Djassoa G, Heuschkel C, Schulz-Key H, Hamm DM, Stingl P. abstract
Applied field research for comprehensive helminth infection control.
Wien Klin Wochenschr. 2010 Mar;122 Suppl 1:27-30.

Kocherscheidt L, Agossou A, Gantin RG, Hamm DM, Banla M, Soboslay PT. abstract
Cytokine and chemokine responses in adults, newborns and children exposed to Entamoeba histolytica/dispar, Onchocerca volvulus and Plasmodium falciparum.
Pediatr Allergy Immunol. 2010 (Apr 14).

Hübner C, Wiehr S, Kocherscheidt L, Wehrl H, Pichler BJ, Schmid A, Kern P, Soboslay PT. abstract
Effects of in vitro exposure of Echinococcus multilocularis metacestodes to cytostatic drugs on in vivo growth and proliferation of the parasite.
Parasitol Res. 2010; 107:459-63.

2009

Hamm D.M. et al. abstract
Co-infections with Schistosoma haematobium, Necator americanus and Entamoeba histolytica/dispar in children: chemokine and cytokine responses and changes after anti-parasite treatment.
The Journal of Infectious Diseases 2009; 199:1583-91.

Bahamontes-Rosa N, Bucher K, Held J, Robin A, Hoffmann WH, Flitsch SL, Kremsner PG, Kun JF. abstract
In vivo anti-malarial effect of the beta-amino alcohol 1t on Plasmodium berghei.
Parasitol Res. 2009; 104:1459-64.

2008

Kocherscheidt L, Flakowski A-K, Grüner B, Hamm DM, Dietz K, Kern P, Soboslay PT. abstract
Echinococcus multilocularis: Inflammatory and regulatory chemokine responses in patients with progressive, stable and cured alveolar echinococcosis.
Exp. Parasitol. 2008; 119(8): 467-74

Duerr HP, Hoffmann W, Eichner M. abstract
Does resistance to filarial reinfection become leaky over time?
Trends in Parasitology 2008; 24(8): 350-4

Knopp S, Amegbo IK, Hamm DM, Schulz-Key H, Banla M, Soboslay PT. abstract
Antibody and cytokine responses in Dracunculus medinensis patients at distinct states of infection.
Trans R Soc Trop Med Hyg. 2008;102(3):277-83

Hübner MP, Pasche B, Kalaydjiev S, Soboslay PT, Lengeling A, Schulz-Key H, Mitre E, Hoffmann WH. abstract
Microfilariae of the filarial nematode Litomosoides sigmodontis exacerbate the course of LPS-induced sepsis in mice.
Infect Immun. 2008; 76(4) 1668-77

Dittrich AM, Erbacher A, Specht S, Diesner F, Krokowski M, Avagyan A, Stock P, Ahrens B, Hoffmann WH, Hoerauf A, Hamelmann E. abstract
Litomosoides sigmodontis Induces Regulatory T Cells and Inhibits Allergic Sensitization, Airway Inflammation, and Hyperreactivity in a Murine Asthma Model.
J Immunol 2008; 180(3):1792-9

2007

Mai C, Hamm DM, Banla M, Agossou A, Schulz-Key H, Heuschkel C, Soboslay PT. abstract
Onchocerca volvulus-specific antibody and cytokine responses in onchocerciasis patients after 16 years of repeated ivermectin therapy.
Clin Exp Immunol. 2007;147(3):504–512

2006

Hübner MP, Manfras BJ, Margos MC, Eiffler D, Hoffmann WH, Schulz-Key H, Kern P, Soboslay PT. abstract
Echinococcus multilocularis metacestodes modulate cellular cytokine and chemokine release by peripheral blood mononuclear cells in alveolar echinococcosis patients.
Clin Exp Immunol. 2006;145(2):243-251

2005

Soboslay PT, Hamm DM, Pfäfflin F, Fendt J, Banla M, Schulz-Key H. abstract
Cytokine and chemokine responses in patients co-infected with Entamoeba histolytica/dispar, Necator americanus and Mansonella perstans and changes after anti-parasite treatment.
Microbes Infect. 2006;8:238-247

Fendt J, Hamm DM, Banla M, Schulz-Key H, Wolf H, Helling-Giese G, Heuschkel C, Soboslay PT. abstract
Chemokines in onchocerciasis patients after a single dose of ivermectin.
Clin Exp Immunol. 2005;142:318-326

2004

Abrahams-Sandi E, Hoffmann WH, Graeff-Teixeira C, Schulz-Key H, Geiger SM. abstract
Long-term observations on mouse strains experimentally infected with Angiostrongylus costaricensis.
Parasitol Res. 2004 Jun;93(3):230-4.

Geiger SM, Massara CL, Bethony J, Soboslay PT, Correa-Oliveira R. abstract
Cellular responses and cytokine production in post-treatment hookworm patients from an endemic area in Brazil.
Clin Exp Immunol. 2004 May;136(2):334-40.

Kirch AK, Agossou A, Banla M, Hoffmann WH, Schulz-Key H, Soboslay PT abstract
Parasite-specific antibody and cytokine profiles in newborns from Plasmodium falciparum and Entamoeba histolytica/dispar-infected mothers.
Pediatr Allergy Immunol. 2004 Apr;15(2):133-41.

Duerr HP, Dietz K, Schulz-Key H, Buttner DW, Eichner M. abstract
The relationships between the burden of adult parasites, host age and the microfilarial density in human onchocerciasis.
Int J Parasitol. 2004 Mar 29;34(4):463-73.

2003

Kirch AK, Duerr HP, Boatin B, Alley WS, Hoffmann WH, Schulz-Key H, Soboslay PT. abstract
Impact of parental onchocerciasis and intensity of transmission on development and persistence of Onchocerca volvulus infection in offspring: an 18 year follow-up study.
Parasitology. 2003 Oct;127(Pt 4):327-35.

Pfaff AW, Kirch AK, Hoffmann WH, Banla M, Schulz-Key H, Geiger SM, Soboslay PT. abstract
Regulatory effects of IL-12 and IL-18 on Onchocerca volvulus- and Entamoeba histolytica-specific cellular reactivity and cytokine profiles.
Parasite Immunol. 2003 Jun;25(6):325-32.

Duerr HP, Dietz K, Schulz-Key H, Buttner DW, Eichner M. abstract
Density-dependent parasite establishment suggests infection-associated immunosuppression as an important mechanism for parasite density regulation in onchocerciasis.
Trans R Soc Trop Med Hyg. 2003 Mar-Apr;97(2):242-50.

Eger A, Kirch A, Manfras B, Kern P, Schulz-Key H, Soboslay PT. abstract
Pro-inflammatory (IL-1beta, IL-18) cytokines and IL-8 chemokine release by PBMC in response to Echinococcus multilocularis metacestode vesicles.
Parasite Immunol. 2003 Feb;25(2):103-5.

Geiger SM, Hoffmann WH, Soboslay PT, Pfaff AW, Graeff-Teixeira C, Schulz-Key H. abstract
Angiostrongylus costaricensis infection in C57BL/6 mice: MHC-II deficiency results in increased larval elimination but unaltered mortality.
Parasitol Res. 2003 Aug;90(5):415-20. Epub 2003 May 16.

Banla M, Balo KP, Soboslay P, Meda DN, Ouro Djeri S. abstract
Corneal perforated wounds treatment by "thermal contact": report of 25 cases
Dakar Med. 2003;48(2):134-7. French.

2002

Geiger SM, Massara CL, Bethony J, Soboslay PT, Carvalho OS, Correa-Oliveira R. abstract
Cellular responses and cytokine profiles in Ascaris lumbricoides and Trichuris trichiura infected patients.
Parasite Immunol. 2002 Nov-Dec;24(11-12):499-509.

Pfaff AW, Schulz-Key H, Soboslay PT, Taylor DW, MacLennan K, Hoffmann WH. abstract
Litomosoides sigmodontis cystatin acts as an immunomodulator during experimental filariasis.
Int J Parasitol. 2002 Feb;32(2):171-8.

2001

Pit DS, Polderman AM, Baeta S, Schulz-Key H, Soboslay PT. abstract
Parasite-specific antibody and cellular immune responses in human infected with Necator americanus and Oesophagostomum bifurcum.
Parasitol Res. 2001 Sep;87(9):722-9.

Geiger SM, Abrahams-Sandi E, Soboslay PT, Hoffmann WH, Pfaff AW, Graeff-Teixeira C, Schulz-Key H. abstract
Cellular immune responses and cytokine production in BALB/c and C57BL/6 mice during the acute phase of Angiostrongylus costaricensis infection.
Acta Trop. 2001 Sep 1;80(1):59-68.

Duerr HP, Dietz K, Buttner DW, Schulz-Key H. abstract
A stochastic model for the aggregation of Onchocerca volvulus in nodules.
Parasitology. 2001 Aug;123(Pt 2):193-201.

Hoffmann WH, Pfaff AW, Schulz-Key H, Soboslay PT. abstract
Determinants for resistance and susceptibility to microfilaraemia in Litomosoides sigmodontis filariasis.
Parasitology. 2001 Jun;122(Pt 6):641-9. Erratum in: Parasitology 2001 Sep;123(Pt 3):234. Soboslav PT [corrected to Soboslay PT].

Geiger SM, Laitano AC, Sievers-Tostes C, Agostini AA, Schulz-Key H, Graeff-Teixeira C. abstract
Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay.
Mem Inst Oswaldo Cruz. 2001 May;96(4):515-8.

2000

Hoffmann W, Petit G, Schulz-Key H, Taylor D, Bain O, Le Goff L. abstract
Litomosoides sigmodontis in mice: reappraisal of an old model for filarial research.
Parasitol Today. 2000 Sep;16(9):387-9. Review.

Pfaff AW, Schulz-Key H, Soboslay PT, Geiger SM, Hoffmann WH. abstract
The role of nitric oxide in the innate resistance to microfilariae of Litomosoides sigmodontis in mice.
Parasite Immunol. 2000 Aug;22(8):397-405.

Pit DS, Polderman AM, Schulz-Key H, Soboslay PT. abstract
Prenatal immune priming with helminth infections: parasite-specific cellular reactivity and Th1 and Th2 cytokine responses in neonates.
Allergy. 2000 Aug;55(8):732-9.

Wuhrer M, Rickhoff S, Dennis RD, Lochnit G, Soboslay PT, Baumeister S, Geyer R. abstract
Phosphocholine-containing, zwitterionic glycosphingolipids of adult Onchocerca volvulus as highly conserved antigenic structures of parasitic nematodes.
Biochem J. 2000 Jun 1;348 Pt 2:417-23.

Pfaff AW, Schulz-Key H, Soboslay PT, Geiger SM, Hoffmann WH. abstract
Litomosoides sigmodontis: dynamics of the survival of microfilariae in resistant and susceptible strains of mice.
Exp Parasitol. 2000 Feb;94(2):67-74.

1999

Graeff-Teixeira C, Geiger S, Walderich B, Hoffmann W, Abrahams E, Schulz-Key H. abstract
Isolation of Angiostrongylus costaricensis first-stage larvae from rodent feces on a Percoll gradient.
J Parasitol. 1999 Dec;85(6):1170-1.

Soboslay PT, Luder CG, Riesch S, Geiger SM, Banla M, Batchassi E, Stadler A, Schulz-Key H. abstract
Regulatory effects of Th1-type (IFN-gamma, IL-12) and Th2-type cytokines (IL-10, IL-13) on parasite-specific cellular responsiveness in Onchocerca volvulus-infected humans and exposed endemic controls.
Immunology. 1999 Jun;97(2):219-25.

Dreweck CM, Soboslay PT, Schulz-Key H, Gottstein B, Kern P. abstract
Cytokine and chemokine secretion by human peripheral blood cells in response to viable Echinococcus multilocularis metacestode vesicles.
Parasite Immunol. 1999 Aug;21(8):433-8.

Soboslay PT, Geiger SM, Drabner B, Banla M, Batchassi E, Kowu LA, Stadler A, Schulz-Key H. abstract
Prenatal immune priming in onchocerciasis-onchocerca volvulus-specific cellular responsiveness and cytokine production in newborns from infected mothers.
Clin Exp Immunol. 1999 Jul;117(1):130-7.

Geiger SM, Graeff-Teixeira C, Soboslay PT, Schulz-Key H. abstract
Experimental Angiostrongylus costaricensis infection in mice: immunoglobulin isotype responses and parasite-specific antigen recognition after primary low-dose infection.
Parasitol Res. 1999 Mar;85(3):200-5.

1998

Kwa MS, Okoli MN, Schulz-Key H, Okongkwo PO, Roos MH. abstract
Use of P-glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulus.
Int J Parasitol. 1998 Aug;28(8):1235-40.

1997

Dreweck CM, Luder CG, Soboslay PT, Kern P. abstract
Subclass-specific serological reactivity and IgG4-specific antigen recognition in human echinococcosis.
Trop Med Int Health. 1997 Aug;2(8):779-87.

Hoffmann WH, Blanke CH, Maier JM, Luder CG, Schulz-Key H, Soboslay PT. abstract
Antigenicity and specificity of very low molecular weight Onchocerca volvulus polypeptides in the range 2.2-12.5 kD.
Trop Med Int Health. 1997 Jul;2(7):635-45.

Baize S, Wahl G, Soboslay PT, Egwang TG, Georges AJ. abstract
T helper responsiveness in human Loa loa infection; defective specific proliferation and cytokine production by CD4+ T cells from microfilaraemic subjects compared with amicrofilaraemics.
Clin Exp Immunol. 1997 May;108(2):272-8.

Soboslay PT, Geiger SM, Weiss N, Banla M, Luder CG, Dreweck CM, Batchassi E, Boatin BA, Stadler A, Schulz-Key H. abstract
The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection.
Immunology. 1997 Apr;90(4):592-9.

1996

Geiger SM, Hoffmann W, Rapp J, Schulz-Key H, Eisenbeiss WF.
Filariidae: cross-protection in filarial infections.
Exp Parasitol. 1996 Aug;83(3):352-6. No abstract available.

Luder CG, Schulz-Key H, Banla M, Pritze S, Soboslay PT. abstract
Immunoregulation in onchocerciasis: predominance of Th1-type responsiveness to low molecular weight antigens of Onchocerca volvulus in exposed individuals without microfilaridermia and clinical disease.
Clin Exp Immunol. 1996 Aug;105(2):245-53.

1994

Soboslay PT, Luder CG, Hoffmann WH, Michaelis I, Helling G, Heuschkel C, Dreweck CM, Blanke CH, Pritze S, Banla M, et al. abstract
Ivermectin-facilitated immunity in onchocerciasis; activation of parasite-specific Th1-type responses with subclinical Onchocerca volvulus infection.
Clin Exp Immunol. 1994 May;96(2):238-44.

1993

Munk ME, Soboslay PT, Arnoldi J, Brattig N, Schulz-Key H, Kaufmann SH. abstract
Onchocerca volvulus provides ligands for the stimulation of human gamma/delta T lymphocytes expressing V delta 1 chains.
J Infect Dis. 1993 Nov;168(5):1241-7.

Luder CG, Soboslay PT, Prince AM, Greene BM, Lucius R, Schulz-Key H. abstract
Experimental onchocerciasis in chimpanzees: cellular responses and antigen recognition after immunization and challenge with Onchocerca volvulus infective third-stage larvae.
Parasitology. 1993 Jul;107 ( Pt 1):87-97.

Seeber F, Brattig N, Soboslay PT, Pogonka T, Lorz A, Strote G, Beck E, Titanji VP, Lucius R. abstract
Characterization of a recombinant T cell and B cell reactive polypeptide of Onchocerca volvulus.
J Immunol. 1993 Apr 1;150(7):2931-44.

Schulz-Key H, Albrecht W, Heuschkel C, Soboslay PT, Banla M, Gorgen H. abstract
Efficacy of ivermectin in the treatment of concomitant Mansonella perstans infections in onchocerciasis patients.
Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):227-9.

1992

Soboslay PT, Dreweck CM, Hoffmann WH, Luder CG, Heuschkel C, Gorgen H, Banla M, Schulz-Key H. abstract
Ivermectin-facilitated immunity in onchocerciasis. Reversal of lymphocytopenia, cellular anergy and deficient cytokine production after single treatment.
Clin Exp Immunol. 1992 Sep;89(3):407-13.

Lucius R, Kern A, Seeber F, Pogonka T, Willenbucher J, Taylor HR, Pinder M, Ghalib HW, Schulz-Key H, Soboslay P. abstract
Specific and sensitive IgG4 immunodiagnosis of onchocerciasis with a recombinant 33 kD Onchocerca volvulus protein (Ov33).
Trop Med Parasitol. 1992 Sep;43(3):139-45.

Soboslay PT, Weiss N, Dreweck CM, Taylor HR, Brotman B, Schulz-Key H, Greene BM. abstract
Experimental onchocerciasis in chimpanzees. Antibody response and antigen recognition after primary infection with Onchocerca volvulus.
Exp Parasitol. 1992 Jun;74(4):367-80.

Schulz-Key H, Soboslay PT, Hoffmann WH.
Ivermectin-facilitated immunity.
Parasitol Today. 1992 May;8(5):152-3. No abstract available.

1991

Soboslay PT, Dreweck CM, Taylor HR, Brotman B, Wenk P, Greene BM.N abstract
Experimental onchocerciasis in chimpanzees. Cell-mediated immune responses, and production and effects of IL-1 and IL-2 with Onchocerca volvulus infection.
J Immunol. 1991 Jul 1;147(1):346-53.

Awissi D, Heuschkel C, Banla M, Schulz-Key H. abstract
Ivermectin in the treatment of onchocerciasis: feasibility, compliance and efficacy of a mass treatment.
Bull Soc Pathol Exot. 1991;84(5 Pt 5):739-49. French.

1990

Awadzi K, Schulz-Key H, Edwards G, Breckenridge A, Orme M, Gilles H. abstract
The chemotherapy of onchocerciasis. XIV. Studies with mebendazole citrate.
Trop Med Parasitol. 1990 Dec;41(4):383-6.

Dohnal J, Blinn J, Wahl G, Schulz-Key H. abstract
Distribution of microfilariae of Onchocerca lienalis and Onchocerca gutturosa in the skin of cattle in Germany and their development in Simulium ornatum and Culicoides nubeculosus following artificial infestation.
Vet Parasitol. 1990 Jul;36(3-4):325-32.

Jurgens S, Schulz-Key H. abstract
Effect of ivermectin on the vertical distribution of Onchocerca volvulus microfilariae in the skin.
Trop Med Parasitol. 1990 Jun;41(2):165-8.

Schulz-Key H. abstract
Observations on the reproductive biology of Onchocerca volvulus.
Acta Leiden. 1990;59(1-2):27-44.

vor 1990

Taylor HR, Trpis M, Cupp EW, Brotman B, Newland HS, Soboslay PT, Greene BM. abstract
Ivermectin prophylaxis against experimental Onchocerca volvulus infection in chimpanzees.
Am J Trop Med Hyg. 1988 Jul;39(1):86-90.

Unnasch TR, Gallin MY, Soboslay PT, Erttmann KD, Greene BM. abstract
Isolation and characterization of expression cDNA clones encoding antigens of Onchocerca volvulus infective larvae.
J Clin Invest. 1988 Jul;82(1):262-9.

Soboslay PT, Newland HS, White AT, Erttmann KD, Albiez EJ, Taylor HR, Williams PN, Greene BM. abstract
Ivermectin effect on microfilariae of Onchocerca volvulus after a single oral dose in humans.
Trop Med Parasitol. 1987 Mar;38(1):8-10.